MK4MDD

Protein Report

Basic Information
Protein Name Glycogen synthase kinase-3 beta
UniPortKB P49841
No. of Studies (Positive/Negative) 2 (2/0) Help
Type Literature-origin
Positive relationship between Glycogen synthase kinase-3 beta and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description Help
GSK-3beta Karege, 2007 patients and normal controls F(3,36)=8.567; P-value= 0.002 The enzyme activity of Akt decreased significantly [analysis...... The enzyme activity of Akt decreased significantly [analysis of variance (ANOVA): F(3,36)=5.372; p= .003], whereas GSK-3beta activity increased significantly [ANOVA: F(3,36)=8.567; p= .002] in depressed suicide victims and non-suicide subjects but not in non-depressed suicide victims. More...
pGSK3beta Karege F, 2012 patients and normal controls F(3,36)=14.3; P-value<0.001 ANOVA yielded significant variations between groups in beta-...... ANOVA yielded significant variations between groups in beta-catenin (F(3,36)=19.5; p<0.001) and pGSK3beta protein (F(3,36)=14.3; p<0.001) and in tGSK3beta-to-pGSK3beta ratio (F(3,36)=10.9; p<0.001). Fisher tests showed decrease in both groups of MDD and MDD with suicide (MDD+S) for beta-catenin (p<0.001) and pGSK3beta levels (p<0.001) respectively. The tGSK3beta-to-pGSK3beta ratio was increased in MDD and MDD+S subjects (p<0.001). More...

Positive relationships between Glycogen synthase kinase-3 beta and other components at different levels (count: 0) Help
Positive relationship network of Glycogen synthase kinase-3 beta in MK4MDD
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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Glycogen synthase kinase-3 beta and MDD (count: 0)
Negative relationships between Glycogen synthase kinase-3 beta and other components at different levels (count: 0) Help
Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
GSK3B glycogen synthase kinase 3 beta Literature-origin; Protein mapped 7 (6/1)