Gene Report

Basic Information

Approved Symbol	EIF6
Approved Name	eukaryotic translation initiation factor 6
Previous Symbol	EIF3A, ITGB4BP
Previous Name	integrin beta 4 binding protein
Symbol Alias	p27BBP, b(2)gcn
Location	20q11.2
Position	chr20:33866709-33872619 (-)
External Links	Entrez Gene: 3692 Ensembl: ENSG00000242372 UCSC: uc002xbv.1 HGNC ID: 6159
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between EIF6 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Integrin beta 4 binding protein	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between EIF6 and other components at different levels (count: 0)

Positive relationship network of EIF6 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between EIF6 and MDD (count: 0)

Negative relationships between EIF6 and other components at different levels (count: 0)

EIF6 related SNPs in MK4MDD (count: 0)

EIF6 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Eukaryotic translation initiation factor 6	P56537	0(0/0)	Gene mapped

EIF6 related GO terms (count: 11)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005737	cytoplasm	cellular component	IEA
GO:0042273	ribosomal large subunit biogenesis	biological process	IEA
GO:0043022	ribosome binding	molecular function	IDA
GO:0003743	translation initiation factor activity	molecular function	IEA
GO:0005638	lamin filament	cellular component	IEA
GO:0005515	protein binding	molecular function	IPI
GO:0000054	ribosomal subunit export from nucleus	biological process	IEA
GO:0042256	mature ribosome assembly	biological process	IMP
GO:0005634	nucleus	cellular component	IDA
GO:0043023	ribosomal large subunit binding	molecular function	IEA
GO:0005730	nucleolus	cellular component	IDA

EIF6 related KEGG pathways (count: 0)

EIF6 related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
EIF_PATHWAY	eif pathway	Eukaryotic protein translation	The scanning translation initiation model suggests that 40S ...... The scanning translation initiation model suggests that 40S ribosomal subunit preloaded with factors bind to the 5 end of the mRNA near the cap. The 48S subunit moves along the mRNA until it finds the initiation triplet and in complex with tRNA and 60S subunit formed the first peptide bond. Translation control is mostly regulated at the protein initiation step through translation initiation factors such as eIF2 or eIF4. More...

EIF6 related Reactome pathways (count: 0)

EIF6 related interactors from protein-protein interaction data in HPRD (count: 28)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
EIF6	OS9	No	yeast 2-hybrid	16169070
EIF6	ITGB4	No	in vitro;in vivo;yeast 2-hybrid	9374518
EIF6	MRPS31	No	yeast 2-hybrid	16169070
EIF6	C4orf27	No	yeast 2-hybrid	16169070
EIF6	ENOX1	No	yeast 2-hybrid	16169070
EIF6	ABCF1	No	yeast 2-hybrid	16169070
EIF6	GNB2L1	No	in vitro;in vivo;yeast 2-hybrid	14654845
EIF6	FUNDC2	No	yeast 2-hybrid	16169070
EIF6	UPF3B	No	yeast 2-hybrid	16169070
EIF6	3-Sep	No	yeast 2-hybrid	16169070
EIF6	ACAP3	No	yeast 2-hybrid	16169070
EIF6	HIP1	No	yeast 2-hybrid	16169070
EIF6	PRKCB	No	in vitro;in vivo;yeast 2-hybrid	14654845
EIF6	GIT1	No	yeast 2-hybrid	16169070
EIF6	OFD1	No	yeast 2-hybrid	16169070
EIF6	ACTG1	No	yeast 2-hybrid	16169070
EIF6	ALDH2	No	yeast 2-hybrid	16169070
EIF6	WFS1	Yes	yeast 2-hybrid	16169070
EIF6	PSME1	No	yeast 2-hybrid	16169070
EIF6	C1orf103	No	yeast 2-hybrid	16169070
EIF6	RPL6	No	yeast 2-hybrid	16169070
EIF6	KIAA1377	No	yeast 2-hybrid	16169070
EIF6	XRN2	No	yeast 2-hybrid	15231747
EIF6	POLA2	No	yeast 2-hybrid	16169070
EIF6	CRELD1	No	yeast 2-hybrid	16169070
EIF6	USP33	No	yeast 2-hybrid	16169070
EIF6	AKT1S1	No	yeast 2-hybrid	16169070
EIF6	PDHA1	No	yeast 2-hybrid	16169070

Gene Report

Gene mapped GO terms

Gene mapped BioCarta pathways