MK4MDD

Protein Report

Basic Information
Protein Name Disrupted in schizophrenia 1 protein
UniPortKB Q9NRI5
No. of Studies (Positive/Negative) 2 (2/0) Help
Type Literature-origin
Positive relationship between Disrupted in schizophrenia 1 protein and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
DISC1 Sawamura N, 2005 Patients and nomal controls In the the subcellular distribution of this DISC1 isoform,...... In the the subcellular distribution of this DISC1 isoform, assessed by the nuclear to cytoplasmic ratio in the immunoreactivity of the isoform, is significantly changed in brains from patients with SZ and MD. This altered distribution is also observed in those subjects with substance and alcohol abuse. The changes in MD brains are significantly influenced by substance/alcohol abuse as well as postmortem interval; however, the alteration in SZ brains is free from brain-associated confounding factors, although an interaction with substance/alcohol abuse cannot be completely ruled out. More...

Positive relationships between Disrupted in schizophrenia 1 protein and other components at different levels (count: 3) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Positive relationship network of Disrupted in schizophrenia 1 protein in MK4MDD
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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Disrupted in schizophrenia 1 protein and MDD (count: 0)
Negative relationships between Disrupted in schizophrenia 1 protein and other components at different levels (count: 0) Help
Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
DISC1 disrupted in schizophrenia 1 Literature-origin; SNP mapped; Protein mapped 3 (3/0)