MK4MDD

Brain Morphology and Function Report

Basic Information
Name Dentate gyrus
Brain Morphology The dentate gyrus is part of the hippocampal formation.
Brain Function "The dentate gyrus is thought to contribute to the formation of memories. The dentate gyrus may also have a functional role in stress and depression. For instance, neurogenesis has been found to increase in response to chronic treatment with antidepressants. On the contrary, however, the physiological effects of stress, often characterized by release of glucocorticoids such as cortisol, as well as activation of the sympathetic division of the autonomic nervous system, have been shown to inhibit the process of neurogenesis in primates. Both endogenous and exogenous glucocorticoids are known to cause psychosis and depression, implying that neurogenesis in the dentate gyrus may play an important role in modulating symptoms of stress and depression. "
Picture Dentate gyrus From Wiki. Magnify
No. of Studies (Positive/Negative) 5(5/0) Help

Positive relationships between Dentate gyrus and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description Help
dentate gyrus Stockmeier, 2004 patients and normal controls increased by 30%-35% in MDD The density of granule cells and glia in the dentate gyrus a...... The density of granule cells and glia in the dentate gyrus and pyramidal neurons is significantly increased by 30%-35% in MDD. More...
dentate gyrus Gaughran, 2006 patients and normal controls FGFR1 mRNA expression was higher in depression than in the o...... FGFR1 mRNA expression was higher in depression than in the other groups in CA1, CA4 and DG. Overall FGF-2 mRNA expression was higher in DG than in CA1 and CA4. More...

Positive relationships between Dentate gyrus and other components at different levels (count: 3) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Dentate gyrus in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Dentate gyrus and MDD (count: 0)
Negative relationships between Dentate gyrus and other components at different levels (count: 0) Help