Gene Report

Basic Information

Approved Symbol	DEAF1
Approved Name	DEAF1 transcription factor
Previous Name	deformed epidermal autoregulatory factor 1 (Drosophila)
Symbol Alias	NUDR, SPN, ZMYND5
Location	11p15.5
Position	chr11:644225-695740 (-)
External Links	Entrez Gene: 10522 Ensembl: ENSG00000177030 UCSC: uc001lqq.1 HGNC ID: 14677
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; Protein mapped

Positive relationships between DEAF1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
NUDR	Goswami, 2010	patients and normal controls		We found that mRNA concentrations of the 5-HT1D receptor and...... We found that mRNA concentrations of the 5-HT1D receptor and the transcription factors, NUDR and REST, were significantly increased in DR-captured neurons of female MDD subjects compared to female control subjects More...

Positive relationships between DEAF1 and other components at different levels (count: 0)

Positive relationship network of DEAF1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between DEAF1 and MDD (count: 0)

Negative relationships between DEAF1 and other components at different levels (count: 0)

DEAF1 related SNPs in MK4MDD (count: 0)

DEAF1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Deformed epidermal autoregulatory factor 1 homolog	O75398	1(1/0)	Literature-origin

DEAF1 related GO terms (count: 14)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0001843	neural tube closure	biological process	ISS
GO:0005634	nucleus	cellular component	IDA[19668219]
GO:0048706	embryonic skeletal system development	biological process	ISS
GO:0033599	regulation of mammary gland epithelial cell proliferation	biological process	IDA[18826651]
GO:0005515	protein binding	molecular function	IPI
GO:0007281	germ cell development	biological process	TAS[9773984]
GO:0009653	anatomical structure morphogenesis	biological process	TAS[9773984]
GO:0008270	zinc ion binding	molecular function	IEA
GO:0005667	transcription factor complex	cellular component	IEA
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	IEA
GO:0005737	cytoplasm	cellular component	IDA[19668219]; IEA
GO:0006366	transcription from RNA polymerase II promoter	biological process	IEA
GO:0005576	extracellular region	cellular component	IEA
GO:0003677	DNA binding	molecular function	IEA

DEAF1 related KEGG pathways (count: 0)

DEAF1 related BioCarta pathways (count: 0)

DEAF1 related Reactome pathways (count: 0)

DEAF1 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
DEAF1	INTS1	No	yeast 2-hybrid	16169070
DEAF1	ASCC2	No	yeast 2-hybrid	16169070

Gene Report

Gene mapped GO terms