Gene Report

Basic Information

Approved Symbol	DAAM2
Approved Name	dishevelled associated activator of morphogenesis 2
Symbol Alias	KIAA0381
Location	6p21.1
Position	chr6:39760159-39872653 (+)
External Links	Entrez Gene: 23500 Ensembl: ENSG00000146122 UCSC: uc003oow.3 HGNC ID: 18143
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between DAAM2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
DAAM2	Guilloux JP, 2012	patients and normal controls		genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects

Positive relationships between DAAM2 and other components at different levels (count: 0)

Positive relationship network of DAAM2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between DAAM2 and MDD (count: 0)

Negative relationships between DAAM2 and other components at different levels (count: 0)

DAAM2 related SNPs in MK4MDD (count: 0)

DAAM2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Disheveled-associated activator of morphogenesis 2	Q86T65	0(0/0)	Gene mapped

DAAM2 related GO terms (count: 3)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0030036	actin cytoskeleton organization	biological process	IEA
GO:0017048	Rho GTPase binding	molecular function	IEA
GO:0003779	actin binding	molecular function	IEA

DAAM2 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04310	wnt signaling_pathway	Wnt signaling pathway	Wnt proteins are secreted morphogens that are required for b...... Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. More...

DAAM2 related BioCarta pathways (count: 0)

DAAM2 related Reactome pathways (count: 0)

DAAM2 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways