Cognition and Behavior Report

Basic Information

Name	Cognitive performance
No. of Studies (Positive/Negative)	18 (17/1)

Positive relationships betweenCognitive performance and MDD (count: 5)

Name in Literature	Reference	Research Type	Relation Description
cognitive impairment	Ravnkilde, 2002	patients and normal controls	corrected for various confounding factors, confirmed the cur...... corrected for various confounding factors, confirmed the current notion that depressed patients suffer from wide-spread cognitive impairments. More...
cognitive performance	Hammar, 2010	patients and normal controls	The results indicate that the depressed patients showed impa...... The results indicate that the depressed patients showed impaired cognitive performance on cognitive demanding tasks when symptomatic and that this impairment prevailed after 6 months, despite significant improvement in their depressive symptoms. More...
cognitive estimation	Barabassy, 2010	patients and normal controls	MDD patients overestimated time (before and after observatio...... MDD patients overestimated time (before and after observation) and underestimated quantity. We conclude that MDD patients in old age are impaired to some extent in cognitive estimation and in the ability to correct themselves. More...
cognitive organization	Braw, 2011	patients and normal controls	The depressed patients had deficits in cognitive organizatio...... The depressed patients had deficits in cognitive organization compared to the healthy controls. More...
cognitive impairment	Sarosi, 2011	patients and normal controls	Relative to controls, patients with depression showed signif...... Relative to controls, patients with depression showed significant impairment on most neurocognitive tasks. More...

Positive relationships between Cognitive performance and other level components at different levels (count: 17)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Related Components
Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
cognitive dysfunction		SLC6A4(serotonin transporter gene)	gene	Sarosi, 2011	patients and normal controls		Our results suggest that the presence of STin2.10 and absenc...... Our results suggest that the presence of STin2.10 and absence of STin2.12 may be considered a possible genetic endophenotype for cognitive dysfunction detected in major depressive disorder. More...
cognitive disturbance		Norepinephrine(norepinephrine)	molecule	Ferguson, 2002	patients only		Reboxetine, a selective NRI(norepinephrine reuptake inhibito...... Reboxetine, a selective NRI(norepinephrine reuptake inhibitor), improves symptoms of psychomotor retardation, anxiety and cognitive disturbance during treatment of MDD. Cognitive disturbance and anxiety were improved in three of four trials. More...
cognitive impairment		N200(N270)	neurobiological system	Mao, 2005	patients and normal controls		The results indicate that MDD patients as a group showed cog...... The results indicate that MDD patients as a group showed cognitive decline. N270 is a sensitive index in revealing cognitive impairment. More...
impaired stimulus evaluation		P300(P300)	neurobiological system	Kemp, 2009	patients and normal controls		A subsequent reduction and delay in the P300 was also reveal...... A subsequent reduction and delay in the P300 was also revealed for MDD indicating that the pronounced lack of discrimination in clinical depression may also lead to impaired stimulus evaluation. More...
depression-related cognitive impairment		Cerebellar vermis(cerebellar vermis)	brain morphology and function	Bench, 1992	patients and normal controls	Bonferroni-corrected P-value < 0.05	Comparing patients with and without depression-related cogni...... Comparing patients with and without depression-related cognitive impairment, in the impaired group there were significant increased rCBF in the cerebellar vermis (P less than 0.05 Bonferroni-corrected). More...
depression-related cognitive impairment		left medial frontal gyrus(left medial frontal gyrus)	brain morphology and function	Bench, 1992	patients and normal controls	Bonferroni-corrected P-value < 0.05	Comparing patients with and without depression-related cogni...... Comparing patients with and without depression-related cognitive impairment, in the impaired group there were significant decreases in rCBF in the left medial frontal gyrus (P less than 0.05 Bonferroni-corrected). More...
cognitive disturbance		Dorsolateral prefrontal cortex(dorsolateral prefrontal cortex)	brain morphology and function	Brody, 2001	patients only		Cognitive disturbance [COGN] improvement was associated with...... Cognitive disturbance [COGN] improvement was associated with increasing dorsolateral prefrontal cortex metabolism. More...
cognitive performance		left lentiform nucleus(left lentiform nucleus)	brain morphology and function	Perico, 2005	patients and normal controls		Cognitive performance was directly correlated with rCBF in t...... Cognitive performance was directly correlated with rCBF in the right postero-medial orbitofrontal cortex and in the left lentiform nucleus. More...
cognitive performance		right postero-medial orbitofrontal cortex(right postero-medial orbitofrontal cortex)	brain morphology and function	Perico, 2005	patients and normal controls		Cognitive performance was directly correlated with rCBF in t...... Cognitive performance was directly correlated with rCBF in the right postero-medial orbitofrontal cortex and in the left lentiform nucleus. More...
cognitive disturbance		left dorsal anterior cingulate gyrus(left dorsal anterior cingulate gyrus)	brain morphology and function	Yao, 2009	patients and normal controls		Cognitive disturbance severity was positively correlated wit...... Cognitive disturbance severity was positively correlated with the ReHo (regional homogeneity) in the right orbitofrontal cortex and the left dorsal anterior cingulate gyrus. More...
cognitive disturbance		right orbitofrontal cortex(right orbitofrontal cortex)	brain morphology and function	Yao, 2009	patients and normal controls		Cognitive disturbance severity was positively correlated wit...... Cognitive disturbance severity was positively correlated with the ReHo (regional homogeneity) in the right orbitofrontal cortex and the left dorsal anterior cingulate gyrus. More...
cognitive functions		left superior longitudinal fasciculus(left superior longitudinal fasciculus)	brain morphology and function	Dalby, 2010	patients and normal controls		patients displayed a significantly higher WML density in two...... patients displayed a significantly higher WML density in two white-matter tracts: the left superior longitudinal fasciculus and the right frontal projections of the corpus callosum. These tracts are part of circuitries essential for cognitive and emotional functions. More...
cognitive functions		right frontal projections of the corpus callosum(right frontal projections of the corpus callosum)	brain morphology and function	Dalby, 2010	patients and normal controls		patients displayed a significantly higher WML density in two...... patients displayed a significantly higher WML density in two white-matter tracts: the left superior longitudinal fasciculus and the right frontal projections of the corpus callosum. These tracts are part of circuitries essential for cognitive and emotional functions. More...
encoding of prediction error signals		Anhedonia(anhedonia)	symptoms	Gradin, 2010	patients and normal controls		a disruption in the encoding of prediction error signals con...... a disruption in the encoding of prediction error signals contributes to anhedonia symptoms in depression More...
cognitive impairment		Psychotic symptoms(psychotic major depression)	symptoms	Gomez, 2006	patients and normal controls		PMDs (psychotic major depression) had more severe cognitive ...... PMDs (psychotic major depression) had more severe cognitive impairments compared with NPMDs and HCs with the exception of simple verbal attention. More...
cognitive functioning		Suicide(suicide)	symptoms	Conner, 2007	patients only		lower cognitive functioning was associated with lower levels...... lower cognitive functioning was associated with lower levels of (suicide)planning More...
coping styles involving cognitive restructuring or problem solving		Stress(stress)	environment	Ravindran, 1996	patients and normal controls		The response to a laboratory stressor was directly related t...... The response to a laboratory stressor was directly related to the use of coping styles involving cognitive restructuring or problem solving. More...

Positive relationship network of Cognitive performance in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships betweenCognitive performance and MDD (count: 0)

Negative relationships between Cognitive performance and other level components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
cognitive dysfunction		Depressed mood(depression)	symptoms	Awata, 1998	patients and normal controls		It was not correlated with the severity of depression or glo...... It was not correlated with the severity of depression or global cognitive dysfunction. More...