MK4MDD

Pathway Report

Basic Information
Name Cell cycle_G1/S check point
BioCarta Link ID: G1_PATHWAY
Name: g1 pathway
Brief Description: Cell Cycle: G1/S Check Point
Full Description: The G1/S cell cycle checkpoint controls the passage of eukaryotic cells from the first 'gap' phase (G1) into the DNA synthesis phase (S). Two cell cycle kinases, CDK4/6-cyclin D and CDK2-cyclin E, and the transcription complex that includes Rb and E2F are pivotal in controlling this checkpoint. During G1 phase, the Rb-HDAC repressor complex binds to the E2F-DP1 transcription factors, inhibiting the downstream transcription. Phosphorylation of Rb by CDK4/6 and CDK2 dissociates the Rb-repressor complex, permitting transcription of S-phase genes encoding for proteins that amplify the G1 to S phase switch and that are required for DNA replication. Many different stimuli exert checkpoint control including TGFb, DNA damage, contact inhibition, replicative senescence, and growth factor withdrawal. The first four act by inducing members of the INK4 or Kip/Cip families of cell cycle kinase inhibitors. TGFb additionally inhibits the transcription of Cdc25A, a phosphatase that activates the cell cycle kinases. Growth factor withdrawal activates GSK3b, which phosphorylates cyclin D, leading to its rapid ubiquitination and proteosomal degradation. Ubiquitination, nuclear export, and degradation are mechanisms commonly used to rapidly reduce the concentration of cell-cycle control proteins.
No. of Studies (Positive/Negative) 1 (1/0) Help

Positive relationship between Cell cycle_G1/S check point and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
Cell cycle_G1/S check point Kao CF, 2012 patients and normal controls We found 17 significantly enriched pathways for depression We found 17 significantly enriched pathways for depression

Positive relationships between Cell cycle_G1/S check point and other components at different levels (count: 0) Help
Positive relationship network of Cell cycle_G1/S check point in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
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3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Cell cycle_G1/S check point and MDD (count: 0)
Negative relationships between Cell cycle_G1/S check point and other components at different levels (count: 0) Help
Pathway Cell cycle_G1/S check point related genes in MK4MDD (count: 4)