Gene Report

Basic Information

Approved Symbol	CITED2
Approved Name	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Symbol Alias	MRG1
Location	6q23.3
Position	chr6:139695550-139695787 (-)
External Links	Entrez Gene: 10370 Ensembl: ENSG00000164442 UCSC: uc021zfz.2 HGNC ID: 1987
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CITED2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CITED2	Savitz J, 2013	patients and normal controls	FC=1.28; P-value=0.0031375

Positive relationships between CITED2 and other components at different levels (count: 0)

Positive relationship network of CITED2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CITED2 and MDD (count: 0)

Negative relationships between CITED2 and other components at different levels (count: 0)

CITED2 related SNPs in MK4MDD (count: 0)

CITED2 related proteins in MK4MDD (count: 0)

CITED2 related GO terms (count: 46)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0000790	nuclear chromatin	cellular component	ISS
GO:0008283	cell proliferation	biological process	IDA[15051727]
GO:0010629	negative regulation of gene expression	biological process	IDA[15051727]
GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	biological process	IDA[15051727]
GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia	biological process	IDA[22735262]
GO:0003156	regulation of organ formation	biological process	ISS
GO:0001666	response to hypoxia	biological process	IDA[9887100]; IMP[17906695]
GO:0060971	embryonic heart tube left/right pattern formation	biological process	ISS
GO:0007507	heart development	biological process	IMP[16287139]; ISS
GO:0043066	negative regulation of apoptotic process	biological process	ISS
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[9434189\|15051727]; ISS
GO:0001889	liver development	biological process	ISS
GO:0005515	protein binding	molecular function	IPI[9887100\|11694877\|12586840\|12762840\|15051727\|17932483]
GO:0070986	left/right axis specification	biological process	ISS
GO:0003682	chromatin binding	molecular function	ISS
GO:0001106	RNA polymerase II transcription corepressor activity	molecular function	IDA[22735262]
GO:0060972	left/right pattern formation	biological process	IBA
GO:0003713	transcription coactivator activity	molecular function	IDA[11581164\|11694877\|12586840\|15051727\|22735262]
GO:0045787	positive regulation of cell cycle	biological process	ISS
GO:0030154	cell differentiation	biological process	IEA
GO:0005737	cytoplasm	cellular component	IMP[12586840]
GO:2000020	positive regulation of male gonad development	biological process	ISS
GO:1903506	regulation of nucleic acid-templated transcription	biological process	IDA[12586840]
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[15051727]; IMP[9887100]
GO:1900164	nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	biological process	ISS
GO:0005634	nucleus	cellular component	IDA[9434189\|9887100\|22735262]; IMP[12586840]
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IMP[17906695]
GO:0007530	sex determination	biological process	IBA; ISS
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	biological process	ISS
GO:0035802	adrenal cortex formation	biological process	ISS
GO:0035035	histone acetyltransferase binding	molecular function	IDA[22735262]
GO:0034405	response to fluid shear stress	biological process	IMP[12960175]
GO:0003714	transcription corepressor activity	molecular function	IDA[9887100]; IMP[17906695]
GO:0006351	transcription, DNA-templated	biological process	IEA
GO:0043627	response to estrogen	biological process	IDA[11581164]
GO:0001105	RNA polymerase II transcription coactivator activity	molecular function	IBA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[22735262]; ISS
GO:0060412	ventricular septum morphogenesis	biological process	ISS
GO:0010628	positive regulation of gene expression	biological process	IDA[15051727]
GO:0050693	LBD domain binding	molecular function	IPI[15051727]
GO:0030336	negative regulation of cell migration	biological process	IMP[18054336]
GO:0022409	positive regulation of cell-cell adhesion	biological process	ISS
GO:0007368	determination of left/right symmetry	biological process	ISS
GO:0048536	spleen development	biological process	ISS
GO:0003700	transcription factor activity, sequence-specific DNA binding	molecular function	ISS
GO:0003151	outflow tract morphogenesis	biological process	ISS

CITED2 related KEGG pathways (count: 0)

CITED2 related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
PPARA_PATHWAY	ppara pathway	Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)	The most recognized mechanism by which peroxisome proliferat...... The most recognized mechanism by which peroxisome proliferators regulated gene expresssion is through a PPAR/RXR heterodimeric complex binding to a peroxisome proliferator-response element (PPRE) (classical mechanism). However, there are the possibility of several variations on this theme: 1). The peroxisome proliferator interacts with PPAR that preexists as a DNA complex with associated corepressors proteins. The interaction with ligand causes release of the corepressor and association with a coactivator, resulting in the classical mechanism. 2). The peroxisome proliferator interacts with PPAR as a soluble member of the nucleus. The binding of ligand results in RXR heterodimerization, DNA binding and coactivator recruitment. 3). In this scenario, PPAR exists in the cytosol, perhaps complexed to heat shock protein 90 and/or other chaperones. Binding of peroxisome proliferator causes a conformational change and translocation into the nucleus. Scenarios 4 and 5 require regulation of gene expression via non-classical mechanisms: 4). PPAR is capable of interacting with, and forming DNA binding heterodimers with, several nuclear receptors including the thyroid hormone receptor. The binding site for this non-RXR heterodimer need not be the classic DR-1 motif found in the PPRE. 5). PPAR may participate in the regulation of gene expression witout binding to DNA. By association with transcription factors such as c-jun or p65, PPAR diminishes the ability of AP1 or NFB to bind to their cognate DNA sequences, respectively. Also shown in this scheme are two means to modify the peroxisome proliferator response. Most importantly, growth factor signaling has a pronounced affect on PPAR via post-translational modification. PPAR is a phosphoprotein and its activity is affected by insulin. Several kinase pathways affects PPARa's activity, although the specific kinases and phosphorylation sites have not been conclusively determined. More...

CITED2 related Reactome pathways (count: 0)

CITED2 related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CITED2	EP300	Yes	in vitro;in vivo;yeast 2-hybrid	9887100 , 12586840 , 12778114
CITED2	TFAP2A	No	in vitro;in vivo;yeast 2-hybrid	12586840
CITED2	HIF1A	No	in vitro	12778114
CITED2	LHX2	No	in vitro;in vivo;yeast 2-hybrid	10593900
CITED2	LHX3	No	in vivo;yeast 2-hybrid	10593900
CITED2	TFAP2C	No	in vitro;in vivo;yeast 2-hybrid	12586840 , 11744733
CITED2	CREBBP	Yes	in vivo	9887100

Gene Report

Gene mapped GO terms

Gene mapped BioCarta pathways