Gene Report

Basic Information

Approved Symbol	CCL7
Approved Name	chemokine (C-C motif) ligand 7
Previous Symbol	SCYA6, SCYA7
Previous Name	"small inducible cytokine A7 (monocyte chemotactic protein 3)"
Symbol Alias	MCP-3, NC28, FIC, MARC, MCP3
Name Alias	"monocyte chemoattractant protein 3", "monocyte chemotactic protein 3"
Location	17q11.2-q12
Position	chr17:32598822-32599261 (+)
External Links	Entrez Gene: 6354 Ensembl: ENSG00000108688 UCSC: uc002hhz.4 HGNC ID: 10634
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CCL7 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CCL7	Carvalho LA, 2014	patients and normal controls	FC=6.3; P-value=0.018	Thirty-four of the 47 monocyte inflammatory-related genes w...... Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls More...

Positive relationships between CCL7 and other components at different levels (count: 0)

Positive relationship network of CCL7 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CCL7 and MDD (count: 0)

Negative relationships between CCL7 and other components at different levels (count: 0)

CCL7 related SNPs in MK4MDD (count: 0)

CCL7 related proteins in MK4MDD (count: 0)

CCL7 related GO terms (count: 31)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006954	inflammatory response	biological process	IBA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006874	cellular calcium ion homeostasis	biological process	TAS[10770925]
GO:0008360	regulation of cell shape	biological process	IDA[10072545]
GO:0007010	cytoskeleton organization	biological process	IDA[10072545]
GO:0008009	chemokine activity	molecular function	IDA[10072545]
GO:0071347	cellular response to interleukin-1	biological process	IBA
GO:0070098	chemokine-mediated signaling pathway	biological process	IBA
GO:0006935	chemotaxis	biological process	TAS[9780207]
GO:0005576	extracellular region	cellular component	TAS
GO:0005615	extracellular space	cellular component	IEA
GO:0002548	monocyte chemotaxis	biological process	IBA; IC[10660125]
GO:0071356	cellular response to tumor necrosis factor	biological process	IBA
GO:0010332	response to gamma radiation	biological process	IEA
GO:0007267	cell-cell signaling	biological process	TAS[7916328]
GO:0005515	protein binding	molecular function	IPI[25416956]
GO:0030593	neutrophil chemotaxis	biological process	IBA
GO:0048247	lymphocyte chemotaxis	biological process	IBA
GO:0031727	CCR2 chemokine receptor binding	molecular function	IEA
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IBA
GO:0031726	CCR1 chemokine receptor binding	molecular function	IPI[7545673\|10660125]
GO:0007165	signal transduction	biological process	TAS[10201901\|10770925]
GO:0048245	eosinophil chemotaxis	biological process	IDA[10072545]
GO:2000503	positive regulation of natural killer cell chemotaxis	biological process	IDA[7545673]
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IBA
GO:0071361	cellular response to ethanol	biological process	IEA
GO:0071346	cellular response to interferon-gamma	biological process	IBA
GO:0005623	cell	cellular component	TAS[10770925]
GO:0030335	positive regulation of cell migration	biological process	IDA[7545673]
GO:0043547	positive regulation of GTPase activity	biological process	IBA
GO:0050729	positive regulation of inflammatory response	biological process	IBA
GO:0008201	heparin binding	molecular function	IEA

CCL7 related KEGG pathways (count: 3)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04621	nod like_receptor_signaling_pathway	NOD-like receptor signaling pathway	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. These NLRs include NALP1, NALP3 and Ipaf. The inflammasomes are critical for generating mature proinflammatory cytokines in concert with Toll-like receptor signaling pathway. More...
hsa04060	cytokine cytokine_receptor_interaction	Cytokine-cytokine receptor interaction	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...
hsa04062	chemokine signaling_pathway	Chemokine signaling pathway	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production. More...

CCL7 related BioCarta pathways (count: 0)

CCL7 related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_15344	chemokine receptors_bind_chemokines	Chemokine receptors are cytokine receptors found on the surf...... Chemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of intracellular calcium which leads to chemotaxis. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_14819	peptide ligand_binding_receptors	These receptors, a subset of the Class A/1 (Rhodopsin-like) ...... These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. More...
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...

CCL7 related interactors from protein-protein interaction data in HPRD (count: 16)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CCL7	CCR5	No	in vitro	10477718
CCL7	MMP13	No	in vitro;in vivo	12149192 , 10947989
CCL7	MMP1	No	in vitro;in vivo	12149192 , 10947989
CCL7	CCBP2	No	in vivo	9364936 , 9405404
CCL7	AES	No	yeast 2-hybrid	16169070
CCL7	MMP2	No	in vitro;in vivo;yeast 2-hybrid	10947989 , 12149192
CCL7	FEZ1	No	yeast 2-hybrid	16169070
CCL7	CCRL1	No	in vitro	10734104
CCL7	CCR1	No	in vitro;in vivo	8530354 , 7545673
CCL7	CCR3	No	in vitro	8642344
CCL7	MMP14	Yes	in vitro;in vivo	12149192 , 10947989
CCL7	CCR10	No	in vivo	9364936
CCL7	DARC	No	in vivo	13679391
CCL7	CCR2	No	in vitro	8530354
CCL7	CCL7	Yes	in vitro	9109648
CCL7	MMP3	No	in vitro;in vivo	12149192 , 10947989

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways