
Gene Report
Approved Symbol | CCL7 |
---|---|
Approved Name | chemokine (C-C motif) ligand 7 |
Previous Symbol | SCYA6, SCYA7 |
Previous Name | "small inducible cytokine A7 (monocyte chemotactic protein 3)" |
Symbol Alias | MCP-3, NC28, FIC, MARC, MCP3 |
Name Alias | "monocyte chemoattractant protein 3", "monocyte chemotactic protein 3" |
Location | 17q11.2-q12 |
Position | chr17:32598822-32599261 (+) |
External Links |
Entrez Gene: 6354 Ensembl: ENSG00000108688 UCSC: uc002hhz.4 HGNC ID: 10634 |
No. of Studies (Positive/Negative) | 1(1/0)
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Type | Literature-origin |
Name in Literature | Reference | Research Type | Statistical Result | Relation Description | ![]() |
---|---|---|---|---|---|
CCL7 | Carvalho LA, 2014 | patients and normal controls | FC=6.3; P-value=0.018 | Thirty-four of the 47 monocyte inflammatory-related genes w...... Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls More... |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Literature-origin GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0006954 | inflammatory response | biological process | IBA |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0006874 | cellular calcium ion homeostasis | biological process | TAS[10770925] | |
GO:0008360 | regulation of cell shape | biological process | IDA[10072545] | |
GO:0007010 | cytoskeleton organization | biological process | IDA[10072545] | |
GO:0008009 | chemokine activity | molecular function | IDA[10072545] | |
GO:0071347 | cellular response to interleukin-1 | biological process | IBA | |
GO:0070098 | chemokine-mediated signaling pathway | biological process | IBA | |
GO:0006935 | chemotaxis | biological process | TAS[9780207] | |
GO:0005576 | extracellular region | cellular component | TAS | |
GO:0005615 | extracellular space | cellular component | IEA | |
GO:0002548 | monocyte chemotaxis | biological process | IBA; IC[10660125] | |
GO:0071356 | cellular response to tumor necrosis factor | biological process | IBA | |
GO:0010332 | response to gamma radiation | biological process | IEA | |
GO:0007267 | cell-cell signaling | biological process | TAS[7916328] | |
GO:0005515 | protein binding | molecular function | IPI[25416956] | |
GO:0030593 | neutrophil chemotaxis | biological process | IBA | |
GO:0048247 | lymphocyte chemotaxis | biological process | IBA | |
GO:0031727 | CCR2 chemokine receptor binding | molecular function | IEA | |
GO:0070374 | positive regulation of ERK1 and ERK2 cascade | biological process | IBA | |
GO:0031726 | CCR1 chemokine receptor binding | molecular function | IPI[7545673|10660125] | |
GO:0007165 | signal transduction | biological process | TAS[10201901|10770925] | |
GO:0048245 | eosinophil chemotaxis | biological process | IDA[10072545] | |
GO:2000503 | positive regulation of natural killer cell chemotaxis | biological process | IDA[7545673] | |
GO:0007186 | G-protein coupled receptor signaling pathway | biological process | IBA | |
GO:0071361 | cellular response to ethanol | biological process | IEA | |
GO:0071346 | cellular response to interferon-gamma | biological process | IBA | |
GO:0005623 | cell | cellular component | TAS[10770925] | |
GO:0030335 | positive regulation of cell migration | biological process | IDA[7545673] | |
GO:0043547 | positive regulation of GTPase activity | biological process | IBA | |
GO:0050729 | positive regulation of inflammatory response | biological process | IBA | |
GO:0008201 | heparin binding | molecular function | IEA |
Gene mapped KEGG pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
hsa04062 | chemokine signaling_pathway | Chemokine signaling pathway | Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production. More... | |
hsa04060 | cytokine cytokine_receptor_interaction | Cytokine-cytokine receptor interaction | Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More... | |
hsa04621 | nod like_receptor_signaling_pathway | NOD-like receptor signaling pathway | Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. These NLRs include NALP1, NALP3 and Ipaf. The inflammasomes are critical for generating mature proinflammatory cytokines in concert with Toll-like receptor signaling pathway. More... |
Gene mapped Reactome pathways | |||
ID | Name | Description | |
---|---|---|---|
REACT_15344 | chemokine receptors_bind_chemokines | Chemokine receptors are cytokine receptors found on the surf...... Chemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of intracellular calcium which leads to chemotaxis. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. More... | |
REACT_14819 | peptide ligand_binding_receptors | These receptors, a subset of the Class A/1 (Rhodopsin-like) ...... These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. More... | |
REACT_14828 | class a1_rhodopsin_like_receptors | Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More... | |
REACT_21340 | gpcr ligand_binding | There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More... |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
CCL7 | MMP14 | Yes | in vitro;in vivo | 12149192 , 10947989 | |
CCL7 | CCL7 | Yes | in vitro | 9109648 | |
CCL7 | DARC | No | in vivo | 13679391 | |
CCL7 | MMP3 | No | in vitro;in vivo | 12149192 , 10947989 | |
CCL7 | MMP2 | No | in vitro;in vivo;yeast 2-hybrid | 10947989 , 12149192 | |
CCL7 | AES | No | yeast 2-hybrid | 16169070 | |
CCL7 | MMP1 | No | in vitro;in vivo | 12149192 , 10947989 | |
CCL7 | CCBP2 | No | in vivo | 9364936 , 9405404 | |
CCL7 | CCRL1 | No | in vitro | 10734104 | |
CCL7 | CCR1 | No | in vitro;in vivo | 8530354 , 7545673 | |
CCL7 | CCR3 | No | in vitro | 8642344 | |
CCL7 | MMP13 | No | in vitro;in vivo | 12149192 , 10947989 | |
CCL7 | CCR5 | No | in vitro | 10477718 | |
CCL7 | CCR2 | No | in vitro | 8530354 | |
CCL7 | FEZ1 | No | yeast 2-hybrid | 16169070 | |
CCL7 | CCR10 | No | in vivo | 9364936 |