Gene Report

Basic Information

Approved Symbol	CCL24
Approved Name	chemokine (C-C motif) ligand 24
Previous Symbol	SCYA24
Previous Name	"small inducible cytokine subfamily A (Cys-Cys), member 24"
Symbol Alias	Ckb-6, MPIF-2, eotaxin-2, MPIF2
Name Alias	"CK-beta-6", "myeloid progenitor inhibitory factor 2", "eotaxin-2"
Location	7q11.23
Position	chr7:75452640-75452674 (-)
External Links	Entrez Gene: 6369 Ensembl: ENSG00000106178 UCSC: uc011kga.2 HGNC ID: 10623
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CCL24 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CCL24	Powell TR, 2014	patients and normal controls		The two most robust and reliable biomarkers identified acro...... The two most robust and reliable biomarkers identified across both the discovery and validation cohort were Chemokine (C-C motif) ligand 24 (CCL24) which was consistently transcribed higher amongst MDD patients relative to controls and BPD patients, and C-C chemokine receptor type 6 (CCR6) which was consistently more lowly transcribed amongst MDD patients relative to controls. More...

Positive relationships between CCL24 and other components at different levels (count: 0)

Positive relationship network of CCL24 in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CCL24 and MDD (count: 0)

Negative relationships between CCL24 and other components at different levels (count: 0)

CCL24 related SNPs in MK4MDD (count: 0)

CCL24 related proteins in MK4MDD (count: 0)

CCL24 related GO terms (count: 27)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006954	inflammatory response	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0045766	positive regulation of angiogenesis	biological process	IEA
GO:0070098	chemokine-mediated signaling pathway	biological process	IBA
GO:0006955	immune response	biological process	TAS[10713092]
GO:0007165	signal transduction	biological process	TAS[9104803]
GO:0005615	extracellular space	cellular component	IBA
GO:2000418	positive regulation of eosinophil migration	biological process	IEA
GO:0043547	positive regulation of GTPase activity	biological process	IDA[19525930]
GO:0048020	CCR chemokine receptor binding	molecular function	IBA
GO:0001938	positive regulation of endothelial cell proliferation	biological process	IDA[19525930]
GO:0030593	neutrophil chemotaxis	biological process	IBA
GO:0008360	regulation of cell shape	biological process	IDA[10072545]
GO:0006935	chemotaxis	biological process	TAS[9104803]
GO:0030838	positive regulation of actin filament polymerization	biological process	IDA[19525930]
GO:0071356	cellular response to tumor necrosis factor	biological process	IBA
GO:0030335	positive regulation of cell migration	biological process	IDA[19525930]
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IBA
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IBA
GO:0071347	cellular response to interleukin-1	biological process	IBA
GO:0050729	positive regulation of inflammatory response	biological process	IBA
GO:0048247	lymphocyte chemotaxis	biological process	IBA
GO:0007267	cell-cell signaling	biological process	TAS[9104803]
GO:0002548	monocyte chemotaxis	biological process	IBA
GO:0048245	eosinophil chemotaxis	biological process	IDA[10072545]
GO:0071346	cellular response to interferon-gamma	biological process	IBA
GO:0007010	cytoskeleton organization	biological process	IDA[10072545]
GO:0008009	chemokine activity	molecular function	IDA[10072545]

CCL24 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04062	chemokine signaling_pathway	Chemokine signaling pathway	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production. More...
hsa04060	cytokine cytokine_receptor_interaction	Cytokine-cytokine receptor interaction	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...

CCL24 related BioCarta pathways (count: 0)

CCL24 related Reactome pathways (count: 0)

CCL24 related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways