MK4MDD

Pathway Report

Basic Information
Name Arrhythmogenic right ventricular cardiomyopathy
KEGG Link ID: hsa05412
Name: arrhythmogenic right_ventricular_cardiomyopathy_arvc
Brief Description: Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Full Description: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are progressive myocyte loss and fibrofatty replacement, with a predilection for the right ventricle. A number of genetic studies have identified mutations in various components of the cardiac desmosome that have important roles in the pathogenesis of ARVD/C. Disruption of desmosomal function by defective proteins might lead to death of myocytes under mechanical stress. The myocardial injury may be accompanied by inflammation. Since regeneration of cardiac myocytes is limited, repair by fibrofatty replacement occurs. Several studies have implicated that desmosome dysfunction results in the delocalization and nuclear translocation of plakoglobin. As a result, competition between plakoglobin and beta-catenin will lead to the inhibition of Wnt/beta-catenin signaling, resulting in a shift from a myocyte fate towards an adipocyte fate of cells. The ryanodine receptor plays a crucial part in electromechanical coupling by control of release of calcium from the sarcoplasmic reticulum into the cytosol. Therefore, defects in this receptor could result in an imbalance of calcium homeostasis that might trigger cell death.
No. of Studies (Positive/Negative) 1 (1/0) Help

Positive relationship between Arrhythmogenic right ventricular cardiomyopathy and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
Arrhythmogenic right ventricular cardiomyopathy Kao CF, 2012 patients and normal controls We found 17 significantly enriched pathways for depression We found 17 significantly enriched pathways for depression

Positive relationships between Arrhythmogenic right ventricular cardiomyopathy and other components at different levels (count: 0) Help
Positive relationship network of Arrhythmogenic right ventricular cardiomyopathy in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
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3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Arrhythmogenic right ventricular cardiomyopathy and MDD (count: 0)
Negative relationships between Arrhythmogenic right ventricular cardiomyopathy and other components at different levels (count: 0) Help
Pathway Arrhythmogenic right ventricular cardiomyopathy related genes in MK4MDD (count: 7)