Gene Report

Basic Information

Approved Symbol	ARTN
Approved Name	artemin
Symbol Alias	NBN, EVN, ENOVIN
Name Alias	neublastin, "neurotrophic factor"
Location	1p33-p32
Position	chr1:44398992-44402912 (+)
External Links	Entrez Gene: 9048 Ensembl: ENSG00000117407 UCSC: uc001ckt.3 HGNC ID: 727
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between ARTN and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
ARTN	Otsuki, 2008	patients and normal controls		Reduced expression levels of GDNF, ARTN, and NT-3 mRNAs were...... Reduced expression levels of GDNF, ARTN, and NT-3 mRNAs were found in patients with major depressive disorder in a current depressive state More...

Positive relationships between ARTN and other components at different levels (count: 0)

Positive relationship network of ARTN in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ARTN and MDD (count: 0)

Negative relationships between ARTN and other components at different levels (count: 0)

ARTN related SNPs in MK4MDD (count: 0)

ARTN related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Artemin	Q5T4W7	0(0/0)	Gene mapped

ARTN related GO terms (count: 10)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0008083	growth factor activity	molecular function	IEA
GO:0097021	lymphocyte migration into lymphoid organs	biological process	IEA
GO:0007422	peripheral nervous system development	biological process	IEA
GO:0007411	axon guidance	biological process	TAS
GO:0005615	extracellular space	cellular component	IEA
GO:0005102	receptor binding	molecular function	TAS[9883723]
GO:0007165	signal transduction	biological process	TAS[9883723]
GO:0050930	induction of positive chemotaxis	biological process	IEA
GO:0061146	Peyer's patch morphogenesis	biological process	IEA
GO:0007405	neuroblast proliferation	biological process	TAS[9883723]

ARTN related KEGG pathways (count: 0)

ARTN related BioCarta pathways (count: 0)

ARTN related Reactome pathways (count: 3)

ID	Name	Description
Gene mapped Reactome pathways
REACT_18266	axon guidance	Axon guidance / axon pathfinding is the process by which neu...... Axon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, which senses the guidance cues in the environment through guidance cue receptors and responds by undergoing cytoskeletal changes that determine the direction of axon growth. Guidance cues present in the surrounding environment provide the necessary directional information for the trip. These extrinsic cues have been divided into attractive or repulsive signals that tell the growth cone where and where not to grow. Genetic and biochemical studies have led to the identification of highly conserved families of guidance molecules and their receptors that guide axons. These include netrins, Slits, semaphorins, and ephrins, and their cognate receptors, DCC and or uncoordinated-5 (UNC5), roundabouts (Robo), neuropilin and Eph. In addition, many other classes of adhesion molecules are also used by growth cones to navigate properly which include NCAM and L1CAM. More...
REACT_18312	ncam1 interactions	The neural cell adhesion molecule, NCAM1 is generally consid...... The neural cell adhesion molecule, NCAM1 is generally considered as a cell adhesion mediator, but it is also considered to be a signal transducing receptor molecule. NCAM1 is involved in multiple cis- and trans-homophilic interactions. It is also involved in several heterophilic interactions with a broad range of other molecules, thereby modulating diverse biological phenomena including cellular adhesion, migration, proliferation, differentiation, survival and synaptic plasticity. More...
REACT_18334	ncam signaling_for_neurite_out_growth	The neural cell adhesion molecule, NCAM, is a member of the ...... The neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the nervous system. The role of NCAM in neural differentiation and synaptic plasticity is presumed to depend on the modulation of intracellular signal transduction cascades. NCAM based signaling complexes can initiate downstream intracellular signals by at least two mechanisms: (1) activation of FGFR and (2) formation of intracellular signaling complexes by direct interaction with cytoplasmic interaction partners such as Fyn and FAK. Tyrosine kinases Fyn and FAK interact with NCAM and undergo phosphorylation and this transiently activates the MAPK, ERK 1 and 2, cAMP response element binding protein (CREB) and transcription factors ELK and NFkB. CREB activates transcription of genes which are important for axonal growth, survival, and synaptic plasticity in neurons. NCAM1 mediated intracellular signal transduction is represented in the figure below. The Ig domains in NCAM1 are represented in orange ovals and Fn domains in green squares. The tyrosine residues susceptible to phosphorylation are represented in red circles and their positions are numbered. Phosphorylation is represented by red arrows and dephosphorylation by yellow. Ig, Immunoglobulin domain; Fn, Fibronectin domain; Fyn, Proto-oncogene tyrosine-protein kinase Fyn; FAK, focal adhesion kinase; RPTPalpha, Receptor-type tyrosine-protein phosphatase; Grb2, Growth factor receptor-bound protein 2; SOS, Son of sevenless homolog; Raf, RAF proto-oncogene serine/threonine-protein kinase; MEK, MAPK and ERK kinase; ERK, Extracellular signal-regulated kinase; MSK1, Mitogen and stress activated protein kinase 1; CREB, Cyclic AMP-responsive element-binding protein; CRE, cAMP response elements. More...

ARTN related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
ARTN	GFRA3	No	in vitro;in vivo	9883723
ARTN	ARTN	Yes	in vitro	9883723

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways