Gene Report

Basic Information

Approved Symbol	AKAP8L
Approved Name	A kinase (PRKA) anchor protein 8-like
Symbol Alias	NAKAP95, HAP95
Name Alias	neighbor of A kinase anchoring protein 95
Location	19p13.13-p13.12
Position	chr19:15490859-15529833 (-)
External Links	Entrez Gene: 26993 Ensembl: ENSG00000011243 UCSC: uc002naw.1 HGNC ID: 29857
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between AKAP8L and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
AKAP8L	Guilloux JP, 2012	patients and normal controls		genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects

Positive relationships between AKAP8L and other components at different levels (count: 0)

Positive relationship network of AKAP8L in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between AKAP8L and MDD (count: 0)

Negative relationships between AKAP8L and other components at different levels (count: 0)

AKAP8L related SNPs in MK4MDD (count: 0)

AKAP8L related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
A-kinase anchor protein 8-like	Q9ULX6	0(0/0)	Gene mapped

AKAP8L related GO terms (count: 8)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005515	protein binding	molecular function	IPI[18313049]
GO:0003677	DNA binding	molecular function	IEA
GO:0005634	nucleus	cellular component	TAS[10761695]
GO:0008150	biological_process	biological process	ND
GO:0005737	cytoplasm	cellular component	IEA
GO:0008270	zinc ion binding	molecular function	IEA
GO:0017151	DEAD/H-box RNA helicase binding	molecular function	TAS[10748171]
GO:0016363	nuclear matrix	cellular component	IDA[16391387]

AKAP8L related KEGG pathways (count: 0)

AKAP8L related BioCarta pathways (count: 0)

AKAP8L related Reactome pathways (count: 0)

AKAP8L related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
AKAP8L	EMD	No	in vivo	11034899
AKAP8L	PRKACA	No	in vitro;in vivo	12950172
AKAP8L	TMPO	No	in vitro	12950172 , 12538639 , 11034899
AKAP8L	PRPF40A	No	in vitro	16391387
AKAP8L	LBR	No	in vivo	11034899
AKAP8L	CDC6	No	in vivo	12538639
AKAP8L	DHX9	No	in vitro;in vivo;yeast 2-hybrid	10748171 , 11402034
AKAP8L	AKAP8L	Yes	in vivo	11034899

Gene Report

Gene mapped GO terms