Gene Report

Basic Information

Approved Symbol	AK3
Approved Name	adenylate kinase 3
Previous Symbol	AK6, AK3L1
Previous Name	adenylate kinase 6, "adenylate kinase 3 like 1"
Symbol Alias	AKL3L1
Location	9p24.1
Position	chr9:4709556-4742043 (-)
External Links	Entrez Gene: 50808 Ensembl: ENSG00000147853 UCSC: uc003ziq.2 HGNC ID: 17376
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between AK3 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
AK3	Klempan, 2009	patients and normal controls		Selected differentially expressed genes in BA44 to BA47 (ANO...... Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t) More...

Positive relationships between AK3 and other components at different levels (count: 0)

Positive relationship network of AK3 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between AK3 and MDD (count: 0)

Negative relationships between AK3 and other components at different levels (count: 0)

AK3 related SNPs in MK4MDD (count: 0)

AK3 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
GTP:AMP phosphotransferase, mitochondrial	Q9UIJ7	0(0/0)	Gene mapped

AK3 related GO terms (count: 15)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0004017	adenylate kinase activity	molecular function	IDA[11485571]
GO:0046899	nucleoside triphosphate adenylate kinase activity	molecular function	IDA[11485571]
GO:0046041	ITP metabolic process	biological process	IDA[11485571]
GO:0005524	ATP binding	molecular function	IEA
GO:0005525	GTP binding	molecular function	IEA
GO:0007596	blood coagulation	biological process	TAS
GO:0046051	UTP metabolic process	biological process	IDA[11485571]
GO:0005739	mitochondrion	cellular component	ISS
GO:0046039	GTP metabolic process	biological process	IDA[11485571]
GO:0046033	AMP metabolic process	biological process	IDA[11485571]
GO:0005759	mitochondrial matrix	cellular component	ISS[11485571]; TAS

AK3 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa00240	pyrimidine metabolism	Pyrimidine metabolism

AK3 related BioCarta pathways (count: 0)

AK3 related Reactome pathways (count: 0)

AK3 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways