Gene Report

Basic Information

Approved Symbol	ACTL6B
Approved Name	actin-like 6B
Previous Symbol	ACTL6
Previous Name	actin-like 6
Symbol Alias	BAF53B
Location	7q22
Position	chr7:100240720-100254084 (-)
External Links	Entrez Gene: 51412 Ensembl: ENSG00000077080 UCSC: uc003uvy.3 HGNC ID: 160
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between ACTL6B and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Actin-like 6B	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between ACTL6B and other components at different levels (count: 0)

Positive relationship network of ACTL6B in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ACTL6B and MDD (count: 0)

Negative relationships between ACTL6B and other components at different levels (count: 0)

ACTL6B related SNPs in MK4MDD (count: 0)

ACTL6B related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Actin-like protein 6B	O94805	0(0/0)	Gene mapped

ACTL6B related GO terms (count: 13)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006338	chromatin remodeling	biological process	IDA[11726552]
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	NAS[8804307]
GO:0007399	nervous system development	biological process	IEA
GO:0005730	nucleolus	cellular component	IDA
GO:0006325	chromatin organization	biological process	NAS[10380635]
GO:0005200	structural constituent of cytoskeleton	molecular function	TAS[10380635]
GO:0016514	SWI/SNF complex	cellular component	IDA[8804307]; ISS
GO:0006351	transcription, DNA-dependent	biological process	IEA
GO:0005634	nucleus	cellular component	IDA[10380635]
GO:0003713	transcription coactivator activity	molecular function	NAS[8804307]
GO:0071565	nBAF complex	cellular component	ISS
GO:0005524	ATP binding	molecular function	IEA

ACTL6B related KEGG pathways (count: 0)

ACTL6B related BioCarta pathways (count: 0)

ACTL6B related Reactome pathways (count: 0)

ACTL6B related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
ACTL6B	COQ9	No	yeast 2-hybrid	16169070
ACTL6B	CTBP1	No	in vivo;yeast 2-hybrid	12565893
ACTL6B	SMARCA2	No	in vitro;in vivo	12437990

Gene Report

Literature-origin GO terms

Gene mapped GO terms