MK4MDD

Protein Report

Basic Information
Protein Name 5-hydroxytryptamine receptor 2A
UniPortKB P28223
No. of Studies (Positive/Negative) 8 (7/1) Help
Type Literature-origin
Positive relationship between 5-hydroxytryptamine receptor 2A and MDD (count: 6)
Name in Literature Reference Research Type Statistical Result Relation Description Help
5-HT2 receptor (serotonin-2 receptor) Biver, 1997 patients and normal controls In depressed patients, [18F]altanserin uptake was significan...... In depressed patients, [18F]altanserin uptake was significantly reduced in a region of the right hemisphere including the posterolateral orbitofrontal cortex and the anterior insular cortex. More...
5-HT2 receptor (serotonin-2 receptor) Yatham, 1999 patients only Depressed patients showed a significant decrease in 5-HT2 re...... Depressed patients showed a significant decrease in 5-HT2 receptor binding as measured by setoperone binding in frontal, temporal, parietal, and occipital cortical regions following desipramine treatment. More...
5-HT(2A) receptors Messa, 2003 patients and normal controls The reduction of [(18)F]FESP BI in cortical areas of DN depr...... The reduction of [(18)F]FESP BI in cortical areas of DN depressed, but not of euthymic DT patients suggests an association between the occurrence of depressive symptoms and impairment of cortical 5-HT(2A) receptors. More...
5-HT(2A) receptor Mintun, 2004 patients and normal controls P-value=0.004 5-HT(2A) receptor binding in the hippocampus was reduced by ...... 5-HT(2A) receptor binding in the hippocampus was reduced by 29% in depressed subjects (p =.004). More...
5-HT(2A) receptor Sheline, 2004 patients and normal controls P-value=0.05 Depressed subjects had less hippocampal 5-HT(2A) receptor bi...... Depressed subjects had less hippocampal 5-HT(2A) receptor binding than controls (p = 0.05). More...
5-HT(2A) receptor Shelton, 2009 patients and normal controls The depressed samples showed significantly increased 5-HT(2A...... The depressed samples showed significantly increased 5-HT(2A) receptor abundance relative to controls More...

Positive relationships between 5-hydroxytryptamine receptor 2A and other components at different levels (count: 7) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Positive relationship network of 5-hydroxytryptamine receptor 2A in MK4MDD
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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between 5-hydroxytryptamine receptor 2A and MDD (count: 0)
Negative relationships between 5-hydroxytryptamine receptor 2A and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Literature-origin; SNP mapped; Protein mapped 11 (7/4)